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封閉抗體陰性什麼是封閉抗體陰性

Hot 2Viewed 300 times28-4-2023 07:22 PM

  封閉抗體陰性是怎麼回事呢?它的治療方法是什麼呢?我想很多人應該都不了解,封閉抗體陰性的治療方法主要還是採用配偶白細胞免疫療法,下面大家就一起來看看封閉抗體陰性的原因吧。

什麼是封閉抗體陰性,它的治療方法是什麼呢?下面大家就一起來看看封閉抗體陰性的原因吧。

  封閉抗體陰性

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在正常孕婦的血清中,存在一種抗配偶淋巴細胞的特異性IgG抗體,它可抑制淋巴細胞反應(MLR),封閉母體淋巴細胞對培養的滋養層的細胞毒作用,防止輔助T細胞識別胎兒抗原的抑制物,並可阻止母親免疫系統對胚胎的攻擊。封閉同種抗原刺激的淋巴細胞產生巨噬細胞移動抑制因子(MIF),故稱其為封閉抗體。

  種類

  1、抗溫B細胞抗體

為抗胎兒B淋巴細胞表面HLA-D/DR抗體。

  2、抗冷B細胞抗體

系非HLA冷B抗體,這是封閉抗體陰性的一種下面還有很多種封閉抗體陰性,大家一起來看看。

  3、抗特異性抗體

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對母體輔助T細胞表面HLA-D/DR受體的基因抗體。

  4、抗TLX抗體

是對絨毛及淋巴細胞共同抗原的抗體,可封閉混合淋巴細胞反應。

  5、抗Fc受體的抗體

為封閉丈夫B淋巴細胞上Fc受體的非細胞障礙性抗體。

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  影響

在臨床上,免疫性因素引發的不孕不育約佔10%-15%的比例,其中絕大部分又是抗精子抗體的問題,封閉抗體陰性的,情況相對少見,也很容易被忽視。如果封閉抗體缺乏,就會導致流產。封閉抗體即抗丈夫淋巴細胞抗體(APLA),如果APLA陰性,則需要進行免疫治療。

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