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封閉抗體陰性什麼是封閉抗體陰性(2)

Hot 4Viewed 393 times28-4-2023 07:25 PM

  封閉抗體陰性的原因是什麼

  1、遺傳因素

如果染色體異常、遺傳基因存在缺陷,常見的有精子或者卵子染色體的異常。

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  2、環境因素

  孕婦過多接觸某些化學物質和物理因素,如放射線、高溫和噪音以及不良的生活習慣均可造成封閉抗體陰性。

  3、母體因素

孕婦患急慢性病高熱、嚴重貧血、營養不良、心力衰竭、慢性腎炎, 高血壓等均有可能影響胚胎髮育而致封閉抗體陰性。

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  4、感染因素

  孕期病毒感染、接觸放射性物質、有毒的化學製劑、服用孕期禁止的藥物、高溫、微波、噪聲、過度受刺激等。

  5、免疫因素

  胎兒被視為半同種異體移植物, 胚胎與母體間存在復雜而特殊的免疫關係, 這種關係使胚胎不被排斥, 這就是母體所表現的免疫耐受。

  6、男方因素

如精液中有大量細菌生長、精子畸形率高等。

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  封閉抗體陰性的治療

  對於封閉抗體陰性者,主要採用配偶白細胞免疫療法,增加反復自然流產患者體內封閉抗體水平,等抗體檢測陽性再懷孕,使妊娠得以成功。治療時醫務人員抽取丈夫體內一定量外周血進行離心沉澱機淋巴細胞分離、培養,再回輸到妻子的前臂皮內。懷孕後前再進行一個療程的鞏固治療,確保孕期穩定。一般一個療程4次治療,每次治療間隔2週。

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